Cyclobenzaprine Withdrawal (Flexeril)

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Cyclobenzaprine withdrawal is a process that can occur when abruptly moderating or discontinuing use of this medication.

Flexeril is a discontinued branded formulation of cyclobenzaprine, a muscle relaxant mainly prescribed to treat pain, tenderness, and loss of motion related to muscle spasms.

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Read on to learn about the following issues:

  • What is cyclobenzaprine?
  • Is cyclobenzaprine addictive?
  • Is cyclobenzaprine addictive when used as prescribed?
  • Cyclobenzaprine addiction: how to connect with treatment providers in Southern California.
  • How to engage with a cyclobenzaprine taper off to make Flexeril withdrawal safer and more comfortable.

Cyclobenzaprine Withdrawal Symptoms

Withdrawal from cyclobenzaprine can be characterized by a range of symptoms that may present when someone stops using the medication. While cyclobenzaprine withdrawal is generally milder than withdrawal from substances with more potent addictive potential – opioids and benzodiazepines, for instance – understanding these symptoms is beneficial for anyone who has been using the medication for an extended period.

These are the most common cyclobenzaprine withdrawal symptoms:

  • Nausea and gastrointestinal distress: Individuals may experience mild to moderate nausea, possibly accompanied by upset stomach or digestive discomfort.
  • Headache: Withdrawal could lead to tension headaches or migraines for some individuals as their body adapts to the absence of the medication.
  • Muscle discomfort: Muscle discomfort or tension may arise due to the abrupt cessation of the muscle relaxant effects provided by cyclobenzaprine.
  • Fatigue and irritability: Mild fatigue, combined with feelings of irritability or mood fluctuations, is not uncommon during withdrawal.
  • Insomnia or sleep disturbances: Individuals might face difficulties falling asleep or staying asleep as their body adjusts to changes in medication use.
  • Anxiety and restlessness: Some people may experience heightened anxiety or restlessness as their system adapts to the absence of the medication’s effects.
  • Sweating: Increased perspiration or night sweats could be observed as part of the withdrawal process.

Withdrawal symptoms of cyclobenzaprine can vary widely based on factors such as the duration and dosage of cyclobenzaprine use, individual sensitivity, and overall health. While these symptoms are generally mild, they can still be uncomfortable. 

If you are considering discontinuing cyclobenzaprine or you are experiencing withdrawal symptoms, consult a healthcare professional. They can provide guidance on managing the transition and ensure your safety and well-being throughout the process. Remember that medical support can help you navigate any medication-related changes to minimize discomfort and potential risks.

an image of someone learning about the side effects of cyclobenzaprine

Can Cyclobenzaprine be Abused?

Cyclobenzaprine, classified as a muscle relaxer, has the potential for misuse due to its sedative effects. Although it doesn’t induce the same degree of euphoria as some other addictive substances, some people might misuse the medication for relaxation or to amplify the effects of other substances. Having said that, cyclobenzaprine is not intended for recreational use, and any misuse can trigger adverse health outcomes. Use this medication only as prescribed by a healthcare provider.

Side Effects of Cyclobenzaprine

Like many medications, cyclobenzaprine may cause side effects. While not everyone experiences these effects, understanding them can help inform decision-making and safe usage. These are the most reported side effects from cyclobenzaprine:

Drowsiness and fatigue

One of the most common side effects is drowsiness. Individuals detoxing from cyclobenzaprine might feel excessively tired, which can impact daily activities and alertness.

Dry mouth

Dry mouth (xerostomia) is frequently reported by those taking cyclobenzaprine. This can be alleviated with increased water intake and sugar-free candies.


Those who experience feelings of dizziness, lightheadedness, or even momentary loss of balance should exercise caution while standing up or engaging in activities requiring focus.

Blurred vision

Blurry or unclear vision can be a temporary side effect, affecting visual acuity and clarity.


Cyclobenzaprine can lead to constipation for some individuals, impacting regular bowel movements. Adequate hydration and dietary fiber intake can help mitigate this effect.

Difficulty urinating

Some people might encounter difficulty or discomfort when urinating, possibly due to the medication’s effects on smooth muscle relaxation.

Increased heart rate

In some cases, individuals might experience a faster heart rate – tachycardia – which can be concerning for those with pre-existing heart conditions.

Nervousness or anxiety

An increase in nervousness or heightened anxiety levels can be observed as a side effect of cyclobenzaprine.

Nausea or upset stomach

Gastrointestinal discomfort, including nausea or an upset stomach, may occur while taking this medication.


Headaches are another potential side effect, although less common.

an image of someone getting help for cyclobenzaprine withdrawal

Get Treatment for Cyclobenzaprine Withdrawal at California Detox

If you have used cyclobenzaprine to the extent of developing physical dependence, we can help you reclaim your life at California Detox in Laguna Beach, CA.

While withdrawal from cyclobenzaprine may not be as severe as opioid or benzo withdrawal, our supervised medical detox program still offers the safest and most comfortable pathway to ongoing recovery. After a tapered reduction in dosage, you can move directly into ongoing residential treatment at California Detox.

All treatment programs at our luxury beachside facility deliver personalized and compassionate addiction treatment that blends science-backed and holistic treatments, such as:

  • Psychotherapy (CBT and DBT)
  • MAT (medication-assisted treatment)
  • Group therapy
  • Family therapy
  • Individual therapy
  • Holistic therapies
  • Aftercare planning and support

Take the first crucial step to recovery by calling admissions today at 949.694.8305.


Cyclobenzaprine is commonly prescribed as a muscle relaxer to alleviate muscle pain, spasms, and discomfort associated with musculoskeletal conditions.
Cyclobenzaprine withdrawal is generally manageable without the need for rehab. That said, if someone experiences severe withdrawal symptoms or has a history of substance misuse, seeking medical guidance and support may be beneficial.


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