Can You Get High on Buspirone?

California Detox logo

Updated April 29, 2026

Authored By:

Joe Gilmore

Edited By

Amy Leifeste

Medically Reviewed By

Javier Rodriguez-Winter

Authored By:

Joe Gilmore

Edited By

Amy Leifeste

Medically Reviewed By

Javier Rodriguez-Winter

California Detox logo

Table of Contents

Can You Get High on Buspirone?

Buspirone, commonly known by its brand name BuSpar, is an anti-anxiety medication that has a unique mechanism of action and a relatively low abuse potential. This page examines the potential for buspirone to produce euphoria and psychoactive effects, explores the difference between legitimate therapeutic use and abuse, and addresses safety concerns regarding this widely prescribed anxiety medication.  

What Is Buspirone (BuSpar)? How It Works & Uses

Buspirone (BuSpar) belongs to a class of medications called azapirones, which work differently from traditional anti-anxiety medications like benzodiazepines [1]. Unlike Xanax or Valium, buspirone doesn’t bind to GABA receptors in the brain. Instead, it primarily affects serotonin receptors, especially the 5-HT1A receptor, acting as a partial agonist [2]. The unique mechanism of action makes buspirone effective for treating GAD (generalized anxiety disorder) without causing sedation, dependence, or withdrawal symptoms commonly associated with benzodiazepines. The medication typically takes several weeks to reach full effectiveness, unlike fast-acting anxiety medications that work within hours. Healthcare providers prescribe buspirone for various anxiety-related conditions beyond GAD, including:
  • Social anxiety disorder.
  • Panic disorder (as an adjunctive treatment).
  • Depression-related anxiety symptoms.
The medication comes in tablet form with typical dosages ranging from 5 to 30mg, taken 2 or 3 times daily. Buspirone has a relatively short half-life of 2 to 3 hours, necessitating multiple daily doses to maintain therapeutic levels [3].

Can You Get High on BuSpar?

While buspirone is generally considered to have a low abuse potential, it can produce altered states of consciousness when taken in excessive amounts. That said, these effects are markedly different from the euphoric high associated with other psychoactive substances.

Does BuSpar get you high in the traditional sense?

At therapeutic doses, buspirone produces calming effects without significant euphoria or intoxication. The medication’s gradual onset of action and lack of immediate rewarding effects make it less appealing for recreational use than other anxiety medications like benzos. Buspirone’s abuse potential is much lower than that of benzodiazepines. The DEA (United States Drug Enforcement Administration) has not classified buspirone as a controlled substance due to its medical utility and low likelihood of abuse and addiction. However, this doesn’t mean the medication is entirely without risk when misused.

Does buspirone get you high when taken in large quantities?

Some people report experiencing altered consciousness, including feelings of relaxation, mild euphoria, or dissociation when consuming doses far exceeding prescribed amounts. These effects typically require taking several times the therapeutic dose, dramatically increasing the risk of adverse reactions.

Understanding BuSpar High

A BuSpar high differs substantially from the euphoric effects produced by other recreational substances.

Symptoms

Individuals who misuse buspirone by taking excessive doses may experience a range of physical and psychological symptoms. Physical symptoms include:
  • Dizziness.
  • Lightheadedness.
  • Drowsiness.
  • Sedation.
  • Nausea.
  • Stomach upset.
  • Headaches.
  • Blurred vision.
  • Muscle weakness.
Psychological symptoms include:
  • Mild euphoria or mood elevation.
  • Relaxation.
  • Decreased anxiety.
  • Confusion.
  • Disorientation.
  • Feelings of detachment.
  • Altered perception of time.
The buspirone high is generally described as subtle and less intense than that associated with other psychoactive substances. Many report unpredictable effects that are not consistently pleasurable, possibly contributing to the medication’s reduced abuse potential.

Length of Effects

For anyone wondering, “How long does BuSpar high last?”, the duration of effects from misuse varies depending on the dose consumed, individual metabolism, and other factors. Typically, the effects peak 1 to 2 hours after ingestion and last for 4 to 6 hours, although residual effects may linger for up to 12 hours. The relatively short duration of effects, combined with the unpredictable nature of the high, makes buspirone less attractive for recreational use than other substances with more consistent and longer-lasting effects.

How Does Buspirone Make You Feel?

At prescribed doses, buspirone produces a range of therapeutic effects. When misused, adverse effects may manifest, especially when the medication is taken in large quantities. Therapeutic effects include:
  • Gradual reduction in anxiety symptoms.
  • Improved mood stability.
  • Enhanced ability to cope with stress.
  • Minimal sedation or cognitive impairment.
  • No significant euphoria or intoxication.
The medication’s effects build gradually over several weeks of consistent use, making it challenging to achieve immediate gratification through misuse. This delayed onset is a protective factor against BuSpar abuse. When misused at higher doses, people report experiencing a disconnected feeling, similar to mild dissociation, alongside physical symptoms like dizziness and nausea. This experience is often described as uncomfortable rather than pleasurable.

BuSpar High vs. Xanax High

BuSpar and Xanax are different types of drugs that deliver different highs. Xanax is notorious for being abused and is classified as a Schedule IV controlled substance for this reason [4].

BuSpar high

The BuSpar high is characterized by:
  1. Subtle, gradual onset of effects.
  2. Mild euphoria or mood elevation.
  3. Physical discomfort, including nausea and dizziness.
  4. Unpredictable and inconsistent effects.
  5. Lower risk of tolerance development [5].
  6. Minimal withdrawal symptoms upon discontinuation.

Xanax high

A Xanax high, by contrast, typically involves:
  1. Rapid onset of euphoric effects.
  2. Pronounced relaxation and sedation.
  3. Memory impairment (blackouts).
  4. High potential for tolerance and dependence.
  5. Severe withdrawal symptoms upon cessation [6].
  6. Greater abuse and addiction potential.
The stark differences between the highs delivered by these medications explain why buspirone is often preferred for long-term anxiety treatment, despite some people attempting to misuse it recreationally.

BuSpar Abuse

BuSpar abuse occurs when individuals use the medication in ways other than prescribed, including taking higher doses, more frequent administration, or using alternative routes of consumption. While less common than the abuse of many psychiatric medications, buspirone misuse does occur and can provoke severe health complications. Several factors may drive BuSpar abuse. Some people mistakenly believe that non-controlled substances are entirely safe to misuse, leading to dangerous experimentation with higher doses. Also, the medication’s non-controlled status may make it easier to obtain than other anxiety medications, potentially facilitating abuse. Some people may raise their dose without medical guidance if symptoms persist, which can lead to dependence on higher amounts Beyond this, buspirone may be combined with other substances to enhance or modify their effects, creating dangerous and wholly unpredictable interactions.

Common Ways BuSpar is Abused

BuSpar may be abused in many different ways, such as:
  • Dose escalation – Taking several pills at once or increasing the frequency of doses beyond prescribed intervals to achieve more noticeable effects.
  • Snorting BuSpar – Some people attempt to snort crushed tablets, believing this will produce faster or more intense effects. This method is hazardous and can cause nasal damage and respiratory complications.
  • Combining the medication with other substances – Mixing buspirone with alcohol, other medications, or illicit drugs to enhance psychoactive effects.
  • Stockpiling medications – Saving prescribed doses to take larger amounts at once, creating periods of medication overuse and therapeutic gaps.
  • Obtaining multiple prescriptions – Seeking prescriptions from various healthcare providers to accumulate larger quantities of the medication.

Signs of BuSpar abuse

Identifying the warning signs of buspirone abuse can help inform early intervention and prevent serious complications from developing. Behavioral indicators include:
  • Taking medication more frequently than prescribed.
  • Running out of prescriptions early.
  • Doctor shopping for multiple prescriptions.
  • Defensive behavior when questioned about medication use.
  • Neglecting responsibilities due to the effects of medication.
Physical symptoms include:
  • Persistent dizziness or coordination problems.
  • Frequent nausea or stomach upset.
  • Unusual drowsiness or sedation.
  • Changes in sleep patterns.
  • Unexplained mood swings.
Psychological signs include:
  • Preoccupation with the effects of the medication.
  • Anxiety when unable to access buspirone.
  • Continued use despite adverse outcomes.
  • Loss of interest in previously enjoyed activities.

Is Buspar Addictive?

While buspirone has significantly lower addiction potential than benzodiazepines, it’s not entirely without risk. The medication can cause mild physical dependence, especially with long-term use at higher doses. That said, withdrawal symptoms are typically much milder than the symptoms associated with many other anxiety medications. Some people may develop psychological reliance on the effects of buspirone, particularly if they’ve experienced anxiety relief from the medication.

Risks of Misuse

Despite its relatively favorable safety profile, buspirone misuse carries some risks:
  • High doses can cause changes in heart rate and blood pressure, which can be potentially dangerous for those with underlying cardiac conditions.
  • Excessive amounts may cause significant sedation, coordination problems, and cognitive impairment.
  • Buspirone can interact with numerous medications, and these interactions may be amplified when the drug is misused.
  • Inappropriate use may interfere with the proper diagnosis and treatment of underlying mental health conditions.
  • Buspirone misuse may trigger serotonin syndrome, a potentially life-threatening condition, when combined with other serotonergic medications.

Buspirone and Alcohol: The Dangers of Mixing The Two

The combination of buspirone and alcohol is a hazardous form of substance abuse that can trigger serious health complications and potentially fatal outcomes. Alcohol is a central nervous system depressant that can amplify the effects of buspirone, creating unpredictable and damaging interactions. Many people underestimate the risks associated with this combination, viewing buspirone as safer than other psychiatric medications and alcohol as a legal and socially sanctioned substance.

Why mixing buspirone and alcohol is dangerous?

Buspirone and alcohol combined can be dangerous because both cause sedation and cognitive impairment. When taken together, these effects intensify and may lead to dangerously reduced alertness and impaired functioning. Alcohol can interfere with the liver’s ability to metabolize buspirone, leading to higher and more prolonged drug concentrations in the body. The combination amplifies the side effects associated with both substances and may produce unexpected psychological effects, including increased anxiety, paranoia, or dissociation.

Symptoms of mixing BuSpar and alcohol

Individuals who combine buspirone and alcohol may experience a range of concerning symptoms. Immediate effects include:
  • Severe dizziness and loss of balance.
  • Extreme drowsiness and sedation.
  • Nausea and vomiting.
  • Difficulty breathing.
  • Confusion and disorientation.
  • Impaired judgment and decision-making.
Potentially severe complications include:
  • Respiratory depression.
  • Dangerous falls or accidents.
  • Loss of consciousness.
  • Memory blackouts.
  • Cardiac rhythm disturbances.
The severity of these effects can vary widely based on the amount of each substance consumed, individual tolerance, body weight, and overall health status.

FAQs

What does BuSpar high feel like?

A BuSpar high typically involves mild euphoria, relaxation, and dizziness, but uncomfortable side effects like nausea and confusion often accompany it. The experience is generally less pleasant and more unpredictable than highs from other substances.

Can buspirone cause euphoria?

Buspirone can cause mild euphoria when taken in doses much higher than prescribed, although this effect is inconsistent and often overshadowed by unpleasant side effects. At therapeutic doses, euphoria is rare.

How long does BuSpar high last?

A BuSpar high typically peaks within 1 to 2 hours and can last 4 to 6 hours total, with some residual effects persisting up to 12 hours. The duration varies based on dosage and individual factors.

Can buspirone feel like Xanax?

Buspirone does not feel like Xanax, as it lacks the immediate sedating and euphoric effects characteristic of benzodiazepines. Buspirone’s effects are much more subtle and develop gradually over time.

What happens if you take too much buspirone?

Taking excessive amounts of buspirone can result in overdose symptoms, including severe dizziness, sedation, nausea, vomiting, and potentially dangerous cardiovascular effects. Medical attention should be sought immediately if an overdose is suspected, as complications can include respiratory depression and loss of consciousness.

Is it safe to stop buspirone suddenly?

While buspirone withdrawal is generally milder than benzodiazepine discontinuation, abrupt cessation can still cause uncomfortable symptoms, including rebound anxiety, irritability, and physical discomfort. Healthcare providers typically recommend a gradual dose reduction under medical supervision to minimize withdrawal effects and prevent symptom recurrence.

Is buspirone addictive in the clinical sense?

Most medical professionals consider buspirone to have a low addiction potential because it does not cause significant euphoria, has a gradual onset of action, causes minimal withdrawal symptoms, and shows little tolerance development at therapeutic doses.  

Get Help with Prescription Drug Misuse at a Premier Rehab Center in California

If you need help addressing prescription drug addiction, reach out to California Detox in Laguna Beach, CA, today. We treat all types of addictions with inpatient programs at our beachside facility. We also offer detox services to streamline the withdrawal process and dual diagnosis treatment programs for those battling substance abuse and co-occurring mental health conditions. All California Detox treatment plans are tailored to individual needs, with therapies such as:
  • Group therapy.
  • Individual counseling.
  • Family therapy.
  • Psychotherapies.
  • Medication management.
  • Motivational therapies.
  • Holistic treatments.
  • Aftercare planning.
Move beyond prescription drug addiction today by calling admissions at 888-995-4208. Sources [1] https://www.sciencedirect.com/topics/neuroscience/azapirone [2] https://www.ncbi.nlm.nih.gov/books/NBK531477/ [3] https://www.pathway.md/ai/history/78e9b666-c596-468d-aac6-8f0b6dfd5805 [4] https://www.deadiversion.usdoj.gov/schedules/schedules.html [5] https://pubmed.ncbi.nlm.nih.gov/11224198/ [6] https://pubmed.ncbi.nlm.nih.gov/7841856/

Related Pages

Request a Call