Managing and reducing the symptoms of Attention Deficit Hyperactivity Disorder (ADHD) usually requires the administration of prescribed stimulants along with behavioral therapy. For decades, two amphetamine medications, Dexedrine (Dextroamphetamine) and Adderall (Amphetamine/Dextroamphetamine), have been used to treat ADHD. These medications are also used for treating narcolepsy, a neurological disorder involving severe daytime drowsiness. Although Adderall continues to be the popular drug of choice, Dexedrine has lost its appeal. There are many differences between the two medications, which often makes people ask the question: “Dextroamphetamine vs Adderall, which is the better choice?” This article compares Adderall and Dexedrine by examining their effects, strengths, safety concerns, and potential for addiction. If you or someone close to you is struggling with prescription medication dependency or addiction, California Detox can provide the necessary help to break the cycle of abuse.  

What Is Adderall?

Adderall is a central nervous system stimulant frequently prescribed for ADHD and narcolepsy treatment [1]. Adderall consists of two stimulants: D-amphetamine and L-amphetamine. This combination enhances concentration, controls hyperactivity, and minimizes impulsive actions in individuals with ADHD. For individuals with narcolepsy, Adderall can assist in maintaining focus and alertness throughout the day. The two active components in Adderall produce somewhat distinct effects. D-amphetamine is more potent and takes effect rapidly, while L-amphetamine produces a gentler and more prolonged impact. Combining these substances allows Adderall to deliver a comparatively stable effect, characterized by rapid symptom alleviation followed by a more gradual release. Adderall is available in two types: Adderall IR (immediate-release tablets) and Adderall XR (extended-release capsules). IR tablets begin functioning in 30 to 60 minutes and last for 4 to 6 hours. XR capsules can last for as long as 12 hours, offering better symptom management and typically requiring just one dose per day.

What Is Dexedrine?

Dexedrine, generically known as D-amphetamine, is a stimulant drug that, like Adderall, is primarily utilized for treating ADHD and narcolepsy [2]. It activates the CNS (central nervous system), aiding in enhancing focus, decreasing impulsive actions, and extending attention span in individuals with ADHD. Dexedrine can also assist people with narcolepsy in remaining alert throughout the day. D-amphetamine is regarded as stronger than several other variations of this medication. This compound enhances specific brain chemicals (neurotransmitters), particularly norepinephrine and dopamine. These chemicals regulate energy levels, mood, and concentration, assisting individuals with ADHD in coping with symptoms of hyperactivity and impulsiveness. Dexedrine is available as capsules and tablets. The tablet version typically features an immediate-release formulation, meaning it acts rapidly and the effects generally last for a few hours. The capsule version (Dexedrine Spansule) is an extended-release formulation meant to release the medication into the system slowly over the day, which reduces the number of doses needed and makes the effects last longer.

Dexedrine vs. Adderall: How to Take Each

When it comes to Dexedrine vs Adderall, Dexedrine is only sanctioned by the Food and Drug Administration (FDA) for treating ADHD in children aged 3 to 16. Moreover, Dexedrine consists of only the most potent type of amphetamine, dextroamphetamine, whereas Adderall consists of a 3:1 proportion of amphetamine and dextroamphetamine. So, if you’re asking yourself: ‘Dextroamphetamine vs Adderall, which is stronger?’, Dexedrine is stronger than Adderall. Additionally, Adderall and Dexedrine differ in their methods of administration and dosages, which vary depending on the specific medication, the condition being treated, and the individual’s personal needs [3]. Physicians typically begin with a small dose and progressively increase it to determine the optimal amount that produces the best results with minimal side effects. Below are the common forms of Dexedrine and Adderall:

• Dexedrine immediate release (IR) is available in two forms: a tablet or a liquid solution
• Adderall immediate release (IR) is available only in tablet form
• Dexedrine and Adderall extended release (XR) are both available in capsule form

Extended-release formulations are typically preferred when the medication needs to last throughout the day without requiring several doses. Nonetheless, immediate-release formulations might be more effective if you seek quick symptomatic relief. Moreover, although the Dextroamphetamine vs Adderall dosage ranges have some similarities, their effects can differ because of their chemical distinctions. Individuals using either medication must adhere to their physician’s recommendations regarding dosage to effectively control symptoms and prevent possible side effects or misuse [3].

Dexedrine Dosing for ADHD

Dexedrine dosage recommendations for ADHD are as follows:

• Tablets or liquid for children aged 3 to 5 years: The initial dose is 2.5 milligrams (mg) once daily in the morning, with the option to increase by 2.5 mg each week if needed.
• Tablets or solution for children aged 6 to 16: Initially prescribed at 5 milligrams once or twice daily. The dosage can be raised by 5 milligrams weekly if needed, but should not exceed 40 milligrams a day. You may take the initial dose in the morning, followed by your second dose four to six hours afterwards.
• Extended-release capsules for children aged 6 and above: Initially administered at 5 milligrams by mouth once each day.

Adderall Dosing for ADHD

Guidelines for Adderall dosing in ADHD consist of the following recommendations: Adderall IR for children ages 3 to 5: Initially administered at 2.5 milligrams each morning. The dosage can be raised by 2.5 milligrams weekly if needed. Adderall IR for individuals aged 6 and older: Initially prescribed at 5 milligrams, administered once or twice each day. You may take the initial dose in the morning, followed by your second dose four to six hours afterward. Do not exceed 40 milligrams in a single day.  Adderall XR for children aged 6 to 12: Initially administered at 5 or 10 milligrams once daily in the morning. Do not exceed 30 milligrams daily. Adderall XR for individuals aged 13 to 17: Initially prescribed at 10 milligrams once daily in the morning. Adderall XR for individuals 18 and older: Initially prescribed at 20 milligrams to be taken orally once each morning.

How Long Do Dexedrine and Adderall Take to Work?

When comparing how long do Adderall vs Dextroamphetamine take to work, both, immediate-release and extended-release Adderall and Dexedrine typically begin to take effect within 30 minutes to one hour. The effects of immediate-release Adderall and Dexedrine generally diminish after four to six hours. Nevertheless, if you consume Adderall extended release, the effects of the medication may persist for as long as 12 hours. Dexedrine extended-release tablets last for eight to ten hours.

Dexedrine Side Effects vs Adderall Side Effects

Since Dexedrine and Adderall fall under the same class of drugs, they share some common side effects [4].

Dexedrine Side Effects

Typical side effects associated with Dexedrine include:

• Increased heart rate
• Migraine
• Tremors
• Sleep disturbances
• Reduced appetite
• Feeling lightheaded
• Stomach problems
• Dry mouth
• Weight loss

Dexedrine has significant side effects that are more likely to happen if an individual misuses the medication. High-risk adverse effects consist of:

• Stroke
• Cardiac arrest
• Elevated heart rate and blood pressure
• Sudden behavioral and mental health symptoms
• Emerging psychotic or manic signs in youth and adolescents
• Reduced growth rate (height and weight) in children
• Alterations in vision, such as blurred vision
• Convulsions

Some of the symptoms listed above might also be seen during Dexedrine overdose. If this is the case, seeking urgent medical help is necessary.

Adderall Side Effects

Adderall can severely harm the cardiovascular system because of the combination of amphetamine and dextroamphetamine. However, as mentioned, most of Adderall’s side effects are similar to those of Dexedrine. They might include:

• Elevated heart rate
• Migraine
• Reduced appetite
• Difficulty sleeping
• Lightheadedness
• Anxiety
• Emotional fluctuations
• Stomach ache
• Dry mouth
• Weight loss 

There are also more severe side effects linked to Adderall, similar to those for Dexedrine. These are more common in individuals who abuse Adderall by taking high, non-medical doses of the drug. Nevertheless, they may appear in individuals using Adderall according to a prescription. Moreover, certain side effects might be linked to overdose, and seeking immediate emergency medical assistance is crucial in such cases:

• Elevated blood pressure and heart rate
• Heart attack
• Stroke
• Circulation issues, such as tingling, numbness, or discomfort in fingers and toes
• Increased or aggravated behavioral or mental health issues
• New symptoms of psychosis or mania in children and teenagers
• Reduced growth in children (weight and height)
• Convulsions
• Alterations in vision or hazy eyesight

Do not mix Adderall with alcohol, as this combination can increase the risk of serious side effects.

Dexedrine vs Adderall Dosages

The dosages of Adderall compared to Dexedrine differ because of the unique chemistry and strength of each medication. Common Dexedrine prescription dosages might involve:

• 5 mg fast-acting tablets, effective for two hours
• 5 mg, 10 mg, and 15 mg extended-release capsules, effective for as long as eight hours
• A prescription of up to 40 mg may be given if symptoms are challenging to manage

In the case of Adderall, a person generally takes three doses of Adderall IR daily to manage ADHD symptoms. Based on FDA approval, only a single XR dose is required, as this formulation lasts for 7-12 hours. Doses for oral tablets include:

• IR formulations  of 5 mg, 7.5 mg, 10 mg, 12.5 mg, 15 mg, 20 mg, 25 mg, and 30 mg
• XR formulas are available in 5 mg increments from 5 mg to 30 mg

Safety Considerations

Schedule II drugs require a written or electronic prescription from a medical professional and are subject to strict rules governing their distribution, storage, and prescribing methods. The designation of these medications as controlled substances guarantees their safe and proper use under medical supervision [5]. Taking Adderall and Dexedrine precisely as directed is crucial. Consuming excessive amounts can lead to an overdose and symptoms like:

• Restlessness
• Tremor
• Rapid breathing
• Hallucinations
• Rhabdomyolysis (muscle injury)

Moreover, you might not be able to use Adderall or Dexedrine if you have any of the following:

• Heart disease
• Hypertension
• Hyperthyroidism
• Glaucoma
• History of monoamine oxidase (MAO) inhibitor use within the past 14 days
• Sensitivity or allergy to other stimulants

Using amphetamines such as Dexedrine or Adderall alongside other medications that elevate serotonin levels in the body can lead to a dangerous condition known as serotonin syndrome. Some of these medications include:

• MAO inhibitors
• Selective serotonin Re-uptake Inhibitors (SSRIs)
• Serotonin Nor-epinephrine Re-uptake Inhibitors (SNRIs)
• Triptans

Hence, before commencing treatment, inform your healthcare provider about all the medication you use, including prescription and over-the-counter (OTC) drugs, dietary supplements, and herbal remedies.

Addiction Potential of Adderall vs Dexedrine

Overall, prescription stimulants such as Adderall and Dexedrine are often abused as many people think these medications can boost cognitive function or enhance memory. In reality, the misuse of these stimulants can result in addiction. Moreover, the prolonged use of both Adderall and Dexedrine can lead to tolerance to the medication. When this happens, an individual must use the medication more often or in larger amounts to attain the same results. Continued use of this drug may lead to the development of a substance use disorder [5]. Adderall, classified as a Schedule II drug, carries the risk of abuse and dependency. Individuals using Adderall must adhere closely to their physician’s guidance and should not exceed the prescribed dosage. Abusing Adderall can lead to serious health issues, such as addiction, alterations in mental health, and cardiovascular problems. Similarly, Dexedrine also presents certain dangers. Dexedrine is also categorized as a Schedule II controlled substance, indicating it has a high risk for abuse and dependency. Individuals must use this medication solely as instructed by a healthcare professional to reduce these risks.

Dexedrine vs. Adderall: Which Is Right For You?

The choice between Dextroamphetamine vs Adderall mostly depends on personal lifestyle, specific needs, and medication response. The safety and efficacy profiles of the two medications are fairly similar. Nonetheless, as individuals react differently to medications, you might discover that your focus improves with one medication rather than the other. Similarly, you may experience side effects with one medication that you don’t have with another. Within a few days of starting a new prescription, you’ll usually know if it’s effective and how well you tolerate the side effects. Ultimately, choosing the right ADHD medication is a collaborative process between you and your doctor. Share your concerns openly, ask questions, and give feedback about any side effects you notice. Be sure to provide your full medical history so your doctor can make the most informed decision and ensure you receive the treatment best suited to your needs.

FAQs

Dextroamphetamine vs Adderall which is stronger? Dextroamphetamine serves as the most potent stimulant component, so the presence of amphetamine in Adderall’s formulation reduces its strength in comparison to dextroamphetamine. What is the strongest ADHD stimulant?  Lisdexamfetamine and mixed amphetamine salts (such as Adderall) are usually considered among the strongest and prescribed stimulant medications for ADHD. However, this varies from person to person. Is dextroamphetamine generic for Adderall?  No. The generic name for Adderall in tablet and capsule form is amphetamine/dextroamphetamine salts. Does dextroamphetamine give you energy? Dextroamphetamine enhances mood and increases motivation. It also boosts energy and confidence levels, along with alertness and focus. Is D-amphetamine salt combo the same as Adderall? The d-amphetamine salt combo is similar to Adderall but is not identical. Adderall consists of a mixture of d-amphetamine and l-amphetamine salts, with a 3:1 ratio that favors d-amphetamine. A drug such as Dexedrine consists solely of d-amphetamine salts. This also influences the time they take to kick in and how long their effects last. Is Dextroamphetamine the same as Adderall? No. While both are central nervous system stimulants, their composition is different. Dextroamphetamine is a single salt medication, whereas Adderall is a combination of d-amphetamine and l-amphetamine. Amphetamine sulfate vs Adderall? Amphetamine sulfate is another type of stimulant medication occasionally prescribed for ADHD, narcolepsy, and similar disorders, but it differs from Adderall. While Adderall contains a combination of amphetamine salts, amphetamine sulfate is a pure version of amphetamine that lacks the mixed-salt compound. What is stronger than Adderall? Medications that include pure d-amphetamine, like Dexedrine, may seem stronger than Adderall due to the use of a single type of amphetamine salt in their formulation.

Get Help for Prescription Drug Addiction at California Detox

If you or a loved one is misusing Adderall or Dexedrine, help is available. California Detox is a drug rehab that offers evidence-based addiction therapies and personalized treatment plans that include:

• Medical detox
• Inpatient residential treatment
• Dual diagnosis for mental health concerns

Discover recovery in a tranquil, nurturing environment at our rehab facility in Laguna Beach, CA. Our skilled clinicians customize every treatment plan to align with your individual recovery goals. Our residents have access to a wide range of services at our luxurious facility, which include:

• Medication management.
• One-to-one counseling.
• Family therapy.
• Group therapy.
• Behavioral therapy.
• Motivational therapy.
• Holistic treatment.
• Aftercare planning.

Our extensive addiction detox program aims to offer you the safest and most supportive setting as you embark on the journey towards a healthier, more productive life. Call our team today at 888-995-4208 and begin your journey towards recovery. Sources [1] https://www.accessdata.fda.gov/drugsatfda_docs/label/2013/021303s026lbl.pdf [2]  https://www.accessdata.fda.gov/drugsatfda_docs/label/2022/017078s054lbl.pdf [3] https://www.verywellhealth.com/dexedrine-vs-adderall-7562803 [4] https://www.verywellhealth.com/dexedrine-vs-adderall-7562803 [5] https://medlineplus.gov/druginfo/meds/a605027.html