How Long Does Suboxone Stay in Your System – Effects & Duration

Updated January 8, 2025

Authored By:

Joe Gilmore

Edited By

Amy Leifeste

Medically Reviewed By

Javier Rodriguez-Winter

Authored By:

Joe Gilmore

Edited By

Amy Leifeste

Medically Reviewed By

Javier Rodriguez-Winter

Table of Contents

How Long Does Suboxone Stay in Your System - Effects & Duration

Suboxone is a medication used to treat opioid addiction. it works by reducing cravings and minimizing withdrawal symptoms. However, people often wonder, “How long does Suboxone stay in your system.

This guide highlights how this medication works, what to expect when taking it, and how it helps people with opioid use disorders recalibrate their lives. You will also discover how to get compassionate and effective treatment for opioid addiction.

What is Suboxone?

Suboxone is a prescription drug that contains two active ingredients: buprenorphine and naloxone. [1] A partial opioid agonist, buprenorphine helps to activate opioid receptors in the brain, similar to other opioids but in a much milder way. This reduces cravings and withdrawal symptoms without producing the intense euphoria associated with opioid use. Naloxone is included to prevent misuse, as it blocks opioid effects if Suboxone is injected or misused.

Used mainly in Suboxone treatment programs, the drug helps people gradually reduce their dependence on opioids. When used as directed, it can be highly effective in helping people stay sober, but its effects and how long does Suboxone stay in your system vary based on individual factors.

How Does Suboxone Work?

Suboxone works by interacting with opioid receptors in the brain, reducing withdrawal symptoms and cravings without creating a high sensation. [2] Buprenorphine binds to opioid receptors, which tricks the brain into thinking it’s receiving the opioid it craves, but at a much lower intensity. This helps stabilize the person and ease them off their addiction gradually. Naloxone, the second ingredient, acts as a deterrent against misuse, as it blocks the effects of opioids when the drug is injected or taken improperly.

This combination makes Suboxone an effective tool against opioid addiction. That said, understanding how long Suboxone stays in your system can help ensure the medication is used correctly, preventing misuse and managing any potential side effects.

How Long Does Suboxone Last?

Once taken, Suboxone reaches peak levels in the bloodstream within 40 minutes to 3 hours. Its effects can last up to 24 hours, making it a once-daily medication for most people undergoing suboxone treatment. However, the actual length of time that Suboxone affects an individual depends on several factors, including metabolism, age, and overall health.

Even though its effects wear off after a day, how long Suboxone stays in your system is a different matter entirely. Depending on the type of drug test administered, it may remain detectable in the body for much longer.

How Long Does Suboxone Stay in Your System?

When considering how long does Suboxone stay in your system, it’s essential to examine both of its active ingredients. Buprenorphine has a half-life of 24 to 42 hours, while naloxone has a shorter half-life of 2 to 12 hours. A drug’s half-life is the amount of time it takes for 50% of a substance to be eliminated from the body.

Given the half-lives of both substances, it can take anywhere from 5 to 8 days for Suboxone to be cleared from a healthy person’s system. In people with liver impairment or slower metabolic rates, it could take up to 2 weeks for Suboxone to leave the system. So, while the effects of Suboxone might wear off after a day, traces of the drug can still be detected long afterward.

How Long Does Suboxone Stay in Your Urine?

Urine tests are the most commonly used drug tests. When it comes to how long Suboxone stays in your urine, it can usually be detected for up to 7 days. In some cases, especially with heavy or long-term use, it may remain detectable for as long as 2 weeks. The exact length of time Suboxone stays in the urine can vary depending on factors like dosage, frequency of use, and the person’s metabolic rate.

Urine tests are favored in many workplaces or medical settings because they are relatively easy to administer and provide a longer detection window than other methods like blood or saliva tests. This means that even if someone hasn’t taken Suboxone for a few days, it could still show up in a urine test. Like other drug tests, factors like age, hydration, and overall health can influence detection times.

How Long Does Suboxone Stay in Your Blood?

How long does Suboxone stay in your blood depends largely on the half-life of buprenorphine. Suboxone is usually detectable in the blood for up to 24 hours after use, with the highest concentration occurring within the first few hours. Blood tests are less commonly used because they are more invasive and have a shorter detection window than urine or hair tests. Nevertheless, they can be effective when an immediate detection of recent Suboxone use is needed.

Blood tests are often reserved for cases where recent use needs to be identified, such as in a medical emergency or when precise drug levels must be measured. While less convenient than urine or saliva tests, blood tests can still play an essential role in determining how long Suboxone stays in your system, especially in clinical settings.

How Long Does Suboxone Stay in Your Saliva?

Saliva tests are also non-invasive and easy to administer. However, how long does Suboxone stay in your saliva is typically shorter than in urine or blood. It is generally detectable in saliva for up to 48 hours after use. This shorter detection period makes saliva tests less effective for long-term tracking but useful for identifying recent use.

Saliva tests are especially useful for situations where rapid results are needed. Because the detection window is shorter, they are more effective in pinpointing very recent Suboxone use rather than determining long-term patterns of use. However, as with other testing methods, individual metabolism and other factors can affect detection times.

Symptoms for Suboxone Abuse

Even though Suboxone is designed to help treat opioid addiction, it is still possible for individuals to abuse the drug. Symptoms of suboxone abuse can include excessive drowsiness, nausea, and mood swings. Long-term abuse can lead to dependence, which may require professional intervention. Identifying these symptoms early can help prevent further abuse and the development of new health issues.

In cases where abuse is suspected, a medical professional may monitor how long Suboxone stays in your system to assess the extent of the abuse and to create a plan for tapering off the medication safely. [3]

Long-term Effects

Prolonged use of Suboxone can have significant long-term effects on the body. For some, it can result in the development of dependence on the drug, requiring ongoing suboxone treatment. Other long-term effects include insomnia, mood changes, and reduced concentration. Although Suboxone is much safer than other opioids, especially when used as prescribed, monitoring usage and understanding how long does Suboxone stay in your system can help avoid long-term complications.

Suboxone Addiction

Although Suboxone is less addictive than full opioid agonists like heroin or morphine, it is still classified as an opioid. This means there is a risk of Suboxone addiction if the drug is not used as prescribed. Individuals may develop dependence, taking higher doses than prescribed or using the drug more frequently. This can trigger an array of health issues and may require a separate course of treatment to manage the addiction.

Understanding how long does Suboxone stay in your system helps in identifying patterns of misuse and deciding when to seek professional help for addiction.

How To Get Suboxone Out of Your System

For individuals who want to stop taking Suboxone, it’s essential to taper off the drug gradually under medical supervision. Abruptly stopping can lead to suboxone withdrawal, which may cause symptoms such as nausea, muscle aches, irritability, and insomnia. Tapering off slowly allows the body to adjust, reducing the intensity of withdrawal symptoms.

Medical detoxification can help manage the process, ensuring that the drug is safely and effectively removed from the body. [4] While detoxing, knowing how long does Suboxone stay in your system allows healthcare providers to develop a plan that minimizes discomfort and prevents relapse. 

Suboxone Withdrawal

Suboxone withdrawal can begin as soon as 48 hours after the last dose and may last for several weeks. The severity of the symptoms varies based on the individual’s level of dependence and how long they have been taking the medication. Common symptoms include anxiety, depression, muscle pain, and gastrointestinal discomfort.

By understanding how long Suboxone stays in your system, medical professionals can design a tapering schedule that gradually decreases the dosage, reducing the chances of severe withdrawal symptoms.

Suboxone Side Effects

While Suboxone is highly effective in managing opioid addiction, it carries the risk of side effects. These can vary from mild to severe, depending on the individual’s body, dosage, and length of treatment. The most frequently reported side effects are mild but can still cause discomfort.

Some of the common side effects include:

  • Headaches: Many people on Suboxone experience headaches, particularly during the first few weeks of treatment. This can be managed by staying hydrated and resting, but in some cases, a doctor may recommend a mild pain reliever.
  • Nausea and vomiting: Suboxone may cause nausea, especially when the drug is first introduced. This can sometimes lead to vomiting, but it generally subsides after the body gets used to the medication.
  • Constipation: Like many opioid-related medications, Suboxone can slow down the digestive system, leading to constipation. Drinking fluids, eating fiber-rich foods, and staying active can help alleviate this issue.
  • Sweating: Excessive sweating is another common side effect of Suboxone. This can be bothersome, particularly at night, but tends to improve with time.

Less common and severe side effects may include:

  • Breathing difficulties: Because Suboxone contains buprenorphine, it can depress the respiratory system, especially when taken in higher doses or when combined with other substances like alcohol or benzodiazepines. Breathing difficulties are a serious side effect and should be addressed immediately by a healthcare provider.
  • Liver damage: Suboxone can affect liver function, especially with long-term use or if the individual already has underlying liver issues. Symptoms of liver problems include yellowing of the eyes or skin or eyes (jaundice), severe fatigue, and dark urine. Regular tests for liver function are often indicated for those on Suboxone treatment to catch any issues early on.
  • Allergic reactions: While rare, some individuals may experience allergic reactions to Suboxone. Symptoms of an allergic reaction can include hives, itching, swelling of the face or throat, and difficulty breathing. This is a medical emergency and requires immediate attention.

Psychological side effects may include:

  • Mood swings: Some individuals experience fluctuations in mood, ranging from irritability to feelings of depression or anxiety. These changes can be attributed to the body’s adjustment to Suboxone and the changes it induces in brain chemistry.
  • Insomnia: Difficulty sleeping or changes in sleep patterns are common in some individuals using Suboxone. Insomnia can be linked to either the drug itself or the withdrawal symptoms from the opioids that the person is trying to quit.
  • Depression: In some cases, Suboxone may worsen feelings of depression, particularly in those who already have a history of mood disorders. Close monitoring by a healthcare provider can help manage these side effects.

Get Compassionate and Evidence-Based Addiction Treatment at a Premier Rehab in California

If you need help for yourself or someone you know dealing with opioid addiction, reach out to California Detox in Laguna Beach, CA.

You will begin your recovery with a medical detox with access to medications like Suboxone and emotional care as you withdraw from opioids under close supervision. After about a week, you can transition to ongoing inpatient treatment at our luxury beachside facility.

All opioid addictions are unique, so all California Detox treatment plans are personalized. Therapies include:

  • Medication-assisted treatment
  • Motivational therapies
  • Talk therapies
  • Counseling
  • Family therapy
  • Group therapy
  • Holistic therapies
  • Aftercare

When you’re ready to begin your recovery from opioid addiction, call 888-995-4208

Sources

[1] https://www.ncbi.nlm.nih.gov/books/NBK603725/

[2] https://nida.nih.gov/publications/drugfacts/prescription-opioids

[3] https://pmc.ncbi.nlm.nih.gov/articles/PMC3150159/

[4] https://www.ncbi.nlm.nih.gov/books/NBK64119

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