Oxycodone Detox: Symptoms, Timeline, & Treatment

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Oxycodone detox is a process that involves discontinuing use of this opioid painkiller under controlled conditions. Supervised medical detoxification for oxycodone minimizes discomfort and complications while reducing the risk of relapse.

Oxycodone Detox Symptoms

Withdrawal symptoms from opioids commonly manifest when someone who is dependent on this class of medication abruptly stops or significantly reduces dosage. Withdrawal symptoms may also present if you take a medication that interferes with the effects of opioids. Tapering off opioids gradually under medical supervision will minimize discomfort during withdrawal.

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Opioid withdrawal symptoms are consistent across different types and may include:

  • Alternating sensations of hot and cold
  • Excessive sweating
  • Anxiety or irritability
  • Cravings for opioids
  • Nausea, vomiting, and diarrhea
  • Appetite loss
  • Tremors
  • Excessive sneezing and tearing
  • Frequent yawning
  • Disrupted sleep patterns

How Long Does It Take to Detox from Oxycodone?

How long to detox from oxycodone varies based on variables like:

  • Duration of use
  • Extent of use
  • Time of last use
  • Severity of physical dependence
  • Co-occurring mental health conditions

Short-acting opioids like oxycodone or heroin can trigger withdrawal symptoms within 6 to 12 hours after the last dose. These symptoms usually peak around two days later and generally subside after about a week.

Detox for long-acting opioids such as methadone, by contrast, involves the manifestation of withdrawal symptoms 1 or 2 days after the last dose. While these symptoms might be milder than those triggered by short-acting opioids, they can last for longer – anywhere from 3 to 6 weeks or more.

Two family members hold hands, as they discuss oxycodone detox symptoms

Treatment for Detoxing from Oxycodone

Effective treatment for detoxing from oxycodone focuses on safely managing withdrawal symptoms and setting a solid foundation for ongoing recovery from opioid addiction.

  • Medically supervised detox: The first step in the treatment process involves a medically supervised detoxification phase. This controlled environment ensures the person’s safety and comfort while withdrawal symptoms are managed by healthcare professionals. Medical supervision allows for immediate response to any complications that may arise during detox.
  • MAT (medication-assisted treatment): MAT is an evidence-based approach that uses FDA-approved medications to reduce cravings and withdrawal symptoms, rendering the detox process more manageable. Medications such as buprenorphine, methadone, and naltrexone are commonly used. Buprenorphine and methadone work by binding to the same opioid receptors in the brain as oxycodone, but without producing the same high, helping to alleviate withdrawal symptoms. Naltrexone blocks opioid receptors, preventing opioids from having their usual effect.
  • Counseling and behavioral therapies: Psychological support through counseling and behavioral therapies helps people address psychological dependence on oxycodone. CBT (cognitive behavioral therapy), motivational therapies, and CM (contingency management) are among the most effective therapeutic approaches that help individuals develop coping strategies, address underlying issues related to their addiction, and build a supportive network for long-term recovery.
  • Support services: Comprehensive detox treatment also includes access to support services that may include group therapy, peer support groups like NA (Narcotics Anonymous), family counseling, and educational programs about addiction and recovery. These services aim to provide emotional support, enhance motivation for recovery, and help people recalibrate their lives from opioid abuse.
  • Aftercare planning: A core component of oxycodone detox treatment is the creation of an aftercare plan to prevent relapse and promote sustained recovery. Aftercare may include ongoing therapy, participation in support groups, and continued use of MAT under medical supervision. Tailoring the aftercare plan to individual needs, circumstances, and goals can help improve long-term treatment outcomes.
  • Holistic treatments: Incorporating holistic therapies such as acupuncture, yoga, meditation, and art therapy can complement traditional treatments by reducing stress, improving mental well-being, and enhancing overall recovery.

How to Detox from Oxycodone Safely

The safest way to detox is under the supervision of medical professionals in a detox center or healthcare facility. Gradually tapering off the drug under medical supervision will help reduce the intensity of withdrawal symptoms and cravings.

During detox, healthcare providers may also prescribe medications to manage specific symptoms like nausea, anxiety, or sleep disturbances. Additionally, staying hydrated, maintaining a balanced diet, and engaging in light physical activity can support the detox process. Seek emotional support from friends, family, or support groups to aid in the recovery journey – you don’t need to fight this battle alone.

inside a room at california detox representing detox from oxycodone

Get Safe Detox for Oxycodone at California Detox

If you feel that you or someone that you care about requires opioid detox and addiction treatment, we can help you at California Detox.

When you detox from oxycodone at our rehab center in Laguna Beach, CA, you can access medications approved by the FDA to treat opioid use disorder. You will also benefit from continuous clinical and emotional care, enabling you to withdraw from opioids as safely and comfortably as possible.

After a week or so, you can move into an ongoing inpatient program at our luxury beachside facility. Due to the unique nature of oxycodone addictions, expect to engage with a personalized array of these therapies:

Call 949.694.8305 today and begin your recovery from oxycodone addiction right away.


Withdrawal symptoms from oxycodone can include nausea, fever, muscle aches, insomnia, and anxiety. Symptoms typically manifest within a few hours to a few days of the last use, varying in intensity according to the severity of physical dependence.
To detox from oxycodone, you can seek treatment at licensed medical detox centers, inpatient rehabs, or hospitals that deliver medically supervised detox programs. These facilities provide support and medical care to manage withdrawal symptoms safely and effectively.


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