Tramadol and alcohol do not mix well, as both substances are central nervous system depressants.
A synthetic opioid, tramadol is sometimes prescribed for the treatment of moderate to severe pain. First appearing in the United States in the 1990s, tramadol is the thirty-fifth most prescribed drug in the US (with almost 20 million prescriptions per 2019 data).Like all opioids, tramadol has the potential for abuse, and it can be addictive. As such, tramadol is a Schedule IV controlled substance. Drugs in this class are deemed to have moderate abuse potential, with physical dependence potentially developing after repeated use. If prescribed tramadol for pain relief, take this medication only as directed.