Trazodone is a prescription antidepressant that is used to treat major depressive disorder.
Today’s guide highlights the side effects potentially triggered by trazadone and the overdose potential of this non-controlled substance.
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Trazodone is a SARI (serotonin receptor antagonist and reuptake inhibitor) antidepressant. This class of medication shares some properties with SSRIs (selective serotonin reuptake inhibitors), the most common second-generation antidepressants.
This medication is only available with a prescription. It is used for the treatment of major depressive disorder. When used for this purpose, trazadone may:
Trazadone has a mechanism of action that is not fully understood. Researchers believe the medication works by increasing the activity of serotonin in the brain. Serotonin is a neurotransmitter or chemical messenger associated with stabilizing mood.
Trazadone is available in generic form. The medication is also sold under various brand names, including:
Your physician will prescribe a trazadone dosage that depends on many factors, such as:
Most physicians initially prescribe a low dosage of trazadone, adjusting the dosage over time if required. 150mg of trazadone in divided doses is a standard starting dosage for adults. Trazadone has not been studied in children and the medication is not indicated for under-18s.
If you are a healthy adult, a single dose of trazodone will be mainly eliminated from your system in between one and three days.
The half-life of trazadone is between five and thirteen hours. Levels of trazadone in the bloodstream will reduce by 50% after one half-life. It will take between four and five elimination half-lives for trazadone to be completely eliminated from your system.
Trazodone was created in the 1960s in Italy as an antidepressant. The medication did not gain initial favor with the medical community due to adverse side effects including:
Over time, clinicians recognized the therapeutic benefits of trazadone, especially in low doses.
The FDA (U.S. Food and Drug Administration) approved Desyrel, the branded version of trazadone, for the treatment of major depressive disorder in 1981.
Today, trazadone is often also prescribed in the form of branded version Oleptro. Oleptro is used for the treatment of major depressive disorder, anxiety disorder, and insomnia.
The most common Trazadone side effects are:
You should seek emergency medical assistance if you notice the following indicators of an allergic reaction to this medication:
Men taking trazadone who experience a painful erection lasting for six hours or more should stop taking the medication immediately and consult their physician. Priapism is considered a medical emergency. Left untreated, the condition may require corrective surgery.
You should consult your doctor if you experience any new or inflamed symptoms of:
Taking too much trazadone can bring on serotonin syndrome. This is a medical emergency that requires immediate intervention. The presentation of symptoms includes:
Although trazadone is a non-addictive medication, it should only be used as prescribed to prevent misuse, especially in individuals with a history of substance abuse.
The sustained use of trazadone can lead to mild physical dependence developing. For this reason, a tapered withdrawal is usually recommended in place of abruptly discontinuing use when treatment is complete.
It is possible to overdose on trazadone, particularly if the medication is mixed with CNS depressants like alcohol, barbiturates, or sedatives.
The symptoms of trazadone overdose include:
Trazadone overdose requires immediate medical intervention.
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