Xylazine Detox: Symptoms, Timeline, & Treatment

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Originally intended for veterinary purposes, Xylazine is a non-opioid sedative and pain reliever, mainly employed to sedate large animals, including horses, deer, and cattle.

In recent years, xylazine has infiltrated the illicit drug scene, being combined with substances like heroin and fentanyl to intensify their effects. This trend has sparked a growing concern over a rising xylazine epidemic, characterized by increased recreational use and the risk of severe side effects and challenging withdrawal symptoms upon discontinuation

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Xylazine Withdrawal Symptoms

Withdrawal from xylazine, especially after prolonged or heavy use, can result in a range of uncomfortable and potentially severe symptoms. Supervised medical detoxification streamlines the intensity of the withdrawal process. Common withdrawal symptoms include:

  • Anxiety and agitation: Individuals detoxing from xylazine may experience heightened levels of anxiety or become easily agitated during the withdrawal period.
  • Physical discomfort: Muscle aches and pains are common signs of withdrawal, along with other physical discomforts that can significantly impact daily functioning.
  • Sleep disturbances: Insomnia or other sleep-related issues frequently occur during xylazine detox, making it difficult to rest properly.
  • Gastrointestinal complications: Nausea, vomiting, and diarrhea can manifest, further complicating the withdrawal process.
  • Cardiovascular changes: Fluctuations in heart rate and blood pressure may be observed, posing additional health risks.
  • Sweating and chills: Withdrawal can trigger episodes of excessive sweating, accompanied by chills or shivering.
  • Intense cravings: A strong desire to use xylazine again can be one of the most challenging withdrawal symptoms to manage.

Those who have been using fentanyl long-term and who have also been exposed to xylazine might experience the development of physical dependence. The exact nature, frequency, and intensity of xylazine withdrawal are not well understood, though. Both individuals and healthcare providers have reported symptoms such as irritability, anxiety, restlessness, and dysphoria associated with xylazine withdrawal. Beyond this, symptoms like rapid heartbeat, sweating, and high blood pressure might manifest within 8 to 24 hours after stopping xylazine.

image of people representing xylazine withdrawal

Xylazine Detox Timeline

Detoxifying from xylazine is a process that varies from person to person, contingent on variables such as the duration and intensity of use. A general timeline, though, can help guide expectations:

  • First 8 to 24 hours: Symptoms may start to appear within this timeframe. Early signs often include irritability, anxiety, restlessness, and possible autonomic symptoms like increased heart rate, sweating, and elevated blood pressure.
  • Days 1 to 3: As the body begins to adjust to the absence of xylazine, symptoms may intensify. This period can be especially challenging, with the continuation of mental discomfort and possibly increasing autonomic symptoms.
  • Days 4 to 7: Symptoms usually start to subside during this phase. Physical symptoms may lessen in intensity, but psychological symptoms like anxiety and restlessness might persist, gradually diminishing over time.
  • Week 2 and beyond: While most acute physical symptoms usually resolve by this stage, some people may continue to experience psychological effects, including cravings and mood swings. The duration of these lingering symptoms can vary widely and may require ongoing support and treatment.

Approach xylazine detox with professional medical supervision to safely manage withdrawal symptoms and address any complications. Additionally, considering the potential for co-occurring substance use disorders, a comprehensive evaluation and tailored detox plan can offer the best chance for a successful recovery.

Xylazine Withdrawal Treatment

Treating xylazine withdrawal involves a combination of medical supervision, symptom management, and supportive care. Given the relatively unknown nature of the process, treatments are adapted based on observed symptoms and individual needs.

  • Medical supervision: Continuous monitoring by healthcare professionals helps to manage the acute symptoms of withdrawal safely and to adjust treatment strategies as necessary.
  • Symptom management: Medications may be administered to alleviate specific symptoms associated with xylazine withdrawal – anxiety, hypertension, and rapid heart rate, for example. Given the similarity of some withdrawal symptoms to those of opioid withdrawal, medications like clonidine, an alpha-2 agonist, have been found beneficial in managing these symptoms – xylazine is an analog of clonidine.
  • Supportive care: Beyond medication, supportive measures such as hydration, nutrition, and rest facilitate the recovery process. Psychological support, including counseling or therapy, can also play an important role in addressing the mental health aspects of withdrawal.
  • Addressing co-occurring substance use: Because xylazine is often used in conjunction with other substances, a comprehensive approach that also addresses potential dependence on other addictive substances may be necessary.
  • Long-term recovery planning: Successful withdrawal management is just the first step in the recovery process. Developing a long-term plan that includes continuous support, counseling, and, if necessary, MAT (medication-assisted treatment) for co-occurring substance use disorders increases the chances of sustained recovery.

Given the complexity of xylazine withdrawal and the potential for severe symptoms, engaging with a specialized addiction treatment program that offers a multidisciplinary approach can provide the most effective support and guidance through the detoxification process and beyond.

How to Detox from Xylazine Safely

Safely detoxing from xylazine requires a structured approach that includes medical oversight and comprehensive support. Initiating detox under the guidance of healthcare professionals experienced in addiction treatment ensures that withdrawal symptoms are effectively managed and complications are promptly addressed. Here’s how you can achieve this.

inside a room at california detox representing Is xylazine withdrawal treatment

Get Treatment for Xylazine Addiction at California Detox

If you need help detoxing from drugs like xylazine, we can help you begin your recovery safely and comfortably at our treatment facility in Laguna Beach, CA.

Supervised medical detoxification reduces the chance of complications or relapse derailing your early efforts at recovery. Detox also streamlines your transition into ongoing treatment, enabling you to address physical dependence on xylazine.

During inpatient treatment at California Detox, you can engage with a personalized blend of the following therapies:

Call 949.694.8305 for immediate assistance.


Safely detoxing from xylazine requires professional medical supervision, as withdrawal symptoms can be aggravating. Healthcare providers might use a combination of medications to manage symptoms and supportive care to address both physical and psychological needs during detoxification. Consult with a healthcare professional or addiction specialist to create a personalized detox plan.
How long it takes to detox from xylazine can vary depending on several factors, including the length of use, dosage, and the individual’s overall health. Generally, acute withdrawal symptoms last from a few days to a week, but some symptoms can persist for longer periods.


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